Unless you are a workaholic, just absolutely love your job, or are super passionate about the service/product you provide, I think it is best to make enough money and find a good hobby, be involved with your family, and voluneer/etc. The job with flexibility, good vacation, and that doesn't make you work more than like 45hrs/week is the best way to go, imo. Find that with the right salary and it is pretty great.