I think Liz's career as a national, elected politician is shot, at least for the foreseeable future. But what she's doing is writing a letter to the future in the hopes that someday, other Republicans will realize there's a way to save the party. Long term, Trumpism will destroy it, otherwise.
In terms of policy, I echo the above sentiments that she's about as hardcore of a conservative as they come. Outside of her willingness to stand up to Trump specifically and only related to his election fuckery (and therefore lose her job), she and I diverge on a lot of issues.