Biggest caveat being in that case, (most) likely Biden wins no matter what in the sense that they are expected to hold the house, and would only need to win 16 seats for that. They currently hold 232 (though looks like they might lose a few) but winning 20 more doesn't seem all that far off to easily win it.
Pf course, if Biden wins any state overall (NV, GA, AZ, NC, etc) that shrinks it by 2 each time.
I'm sure it changes it some, and it definitely would made district races much more interesting as hardly any state is lockstep one or the other, and you'd at least feel like you got the power over a national election in more local ways.