Author Topic: China Did This! (Canadian PM out of hiding . . .finally) Topic: CoronaVirus!  (Read 133565 times)

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Offline sonofdaxjones

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I guess all of those researchers working on the Spike D614G mutation of Covid-19 a few weeks ago are just a giant collection of dumbasses.   :frown:




Offline sonofdaxjones

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One particular subtype with a non-silent (Aspartate to Glycine) mutation at 614th position of the Spike protein (D614G) rapidly outcompeted other pre-existing subtypes,

https://www.biorxiv.org/content/10.1101/2020.05.04.075911v1

Offline sonofdaxjones

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An analysis of 82 coronavirus strains in India showed that nearly 50 per cent of these strains have the new mutation
50 per cent coronavirus strains in India show 'spike' mutation
https://www.timesnownews.com/health/article/coronavirus-mutations-50-virus-strains-in-india-have-new-mutation-d614g-could-make-disease-more-contagious/588789

Online Phil Titola

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Bold, italics, AND underline. :eek:

Online treysolid

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One particular subtype with a non-silent (Aspartate to Glycine) mutation at 614th position of the Spike protein (D614G) rapidly outcompeted other pre-existing subtypes,

https://www.biorxiv.org/content/10.1101/2020.05.04.075911v1

This is mildly misleading because that "out-competition" is heavily reliant upon the genetic make-up of the host

Offline sonofdaxjones

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One particular subtype with a non-silent (Aspartate to Glycine) mutation at 614th position of the Spike protein (D614G) rapidly outcompeted other pre-existing subtypes,

https://www.biorxiv.org/content/10.1101/2020.05.04.075911v1

This is mildly misleading because that "out-competition" is heavily reliant upon the genetic make-up of the host

Translation:  There is no definitive answers as of yet, anyone saying that they have definitive answers or implying that they do is a total and complete dumbass.   Anyone that believes that any SARS-Covid-19 study to dates is the definitive answer is a total moron.




Online michigancat

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Online treysolid

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One particular subtype with a non-silent (Aspartate to Glycine) mutation at 614th position of the Spike protein (D614G) rapidly outcompeted other pre-existing subtypes,

https://www.biorxiv.org/content/10.1101/2020.05.04.075911v1

This is mildly misleading because that "out-competition" is heavily reliant upon the genetic make-up of the host

Translation:  There is no definitive answers as of yet, anyone saying that they have definitive answers or implying that they do is a total and complete dumbass.   Anyone that believes that any SARS-Covid-19 study to dates is the definitive answer is a total moron.

That's not a good "translation" of what I said. The caveat with this particular virus mutation is that it exploits a delC in a specific allele in the host, and the prevalence of this host mutation will have a large impact on transmission.

Offline MakeItRain

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I hate bringing this back to Iowa but our governor is a colossal eff up, she's been far and away the most inept governor in the country in handing this, beating out Brian Kemp by a nose, this is absurd.

https://www.desmoinesregister.com/story/news/2020/05/21/coronavirus-governor-kim-reynolds-test-iowa-site-linn-county-covid/5229515002/

From the second most populated county in the state
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Since the Test Iowa Cedar Rapids site at Kirkwood Community College opened on May 7, Kitzmann wrote there had been 823 tests completed there as of Monday. But officials had received only 20 results by then. Of those, 16 were inconclusive.

She's been repeatedly asked about these issues with Test Iowa and has repeatedly denied that there has been issues.

Also worth noting that as we "open up" today, Iowa had its highest number of new cases since May 11 and the most number of deaths period.

Online michigancat

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I hate bringing this back to Iowa but our governor is a colossal eff up, she's been far and away the most inept governor in the country in handing this, beating out Brian Kemp by a nose, this is absurd.

https://www.desmoinesregister.com/story/news/2020/05/21/coronavirus-governor-kim-reynolds-test-iowa-site-linn-county-covid/5229515002/

From the second most populated county in the state
Quote
Since the Test Iowa Cedar Rapids site at Kirkwood Community College opened on May 7, Kitzmann wrote there had been 823 tests completed there as of Monday. But officials had received only 20 results by then. Of those, 16 were inconclusive.

She's been repeatedly asked about these issues with Test Iowa and has repeatedly denied that there has been issues.

Also worth noting that as we "open up" today, Iowa had its highest number of new cases since May 11 and the most number of deaths period.
I appreciate your Iowa updates. upper Midwest not looking too hot right now.

(Is Iowa upper Midwest?)

Offline Trim

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Canada, at least BC, probably isn't letting us come until 2021.  :frown:

Offline MakeItRain

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I hate bringing this back to Iowa but our governor is a colossal eff up, she's been far and away the most inept governor in the country in handing this, beating out Brian Kemp by a nose, this is absurd.

https://www.desmoinesregister.com/story/news/2020/05/21/coronavirus-governor-kim-reynolds-test-iowa-site-linn-county-covid/5229515002/

From the second most populated county in the state
Quote
Since the Test Iowa Cedar Rapids site at Kirkwood Community College opened on May 7, Kitzmann wrote there had been 823 tests completed there as of Monday. But officials had received only 20 results by then. Of those, 16 were inconclusive.

She's been repeatedly asked about these issues with Test Iowa and has repeatedly denied that there has been issues.

Also worth noting that as we "open up" today, Iowa had its highest number of new cases since May 11 and the most number of deaths period.
I appreciate your Iowa updates. upper Midwest not looking too hot right now.

(Is Iowa upper Midwest?)

Yes

Online treysolid

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Idea to help future-proof pandemics:

Since sports team owners refuse to pay for the construction of their own stadiums/arenas, we should require that they all be built up to code with hospitals (proper ventilation, etc.) so that they can be easily converted during a pandemic. They are conveniently situated in or near urban areas most likely to be affected and won't be in use for sports or concerts anyway during that time.

Online Phil Titola

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We (USA) suck.

?s=19

Online chum1

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Offline wetwillie

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That’s a swimming pool chum
When the bullets are flying, that's when I'm at my best

Online michigancat

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We (USA) suck.

?s=19
Let's just wait till we can test a million a day and an API from google before we do anything

Also

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Analog contact tracing breaks down when infection numbers are high

I've seen this repeated in a few articles and I don't understand it. It seems like you just wouldn't be able to keep numbers down entirely but contact tracing seems like it would still help a lot.

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Offline memphis

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Just so I understand correctly, by mixing in antibody testing it will screw with the new infection numbers from a time perspective.

Does it also have a tendency to drive down infection rate as a function of time? Ie the PCR testing could actually have had rising infection rate and stagnant testing capacity with time during the opening phases? Is that breakdown known?

Online sys

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Analog contact tracing breaks down when infection numbers are high

I've seen this repeated in a few articles and I don't understand it. It seems like you just wouldn't be able to keep numbers down entirely but contact tracing seems like it would still help a lot.

it's just another way for the united states to give up without trying because trying seems hard.
we understand it better now that the american century is over and some of us sound more and more like serbs.

Online michigancat

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Just so I understand correctly, by mixing in antibody testing it will screw with the new infection numbers from a time perspective.

Does it also have a tendency to drive down infection rate as a function of time? Ie the PCR testing could actually have had rising infection rate and stagnant testing capacity with time during the opening phases? Is that breakdown known?

PCR tests tell you who is actively infected, antibody tells you someone had it at some point.

Combining results likely lowers the calculated positive rates because antibody tests are probably more likely to be used for someone who's asymptomatic. There's no real argument for them to be combined unless you're trying to determine herd immunity (and even then I'm not sure it's good to combining them because in theory people could be tested twice).

Online sys

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there's no argument for combining them.

i'm still unsure that positive antibody tests are counted as a new cases (because they shouldn't be, because they aren't new cases).  i think the best that can be done for now in terms of data interpretation is to just ignore the issue and hope/assume the numbers of antibody tests are small.

hopefully the issue is resolved soon.
we understand it better now that the american century is over and some of us sound more and more like serbs.

Online Phil Titola

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I'm even fine with them being counted as new cases but don't mix antibody and pcr in the % positive test count, that sways the numbers and makes them dishonest that we are testing enough of the population to know our active cases which I see as biggest benefit of that metric.

Offline Woogy

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Analog contact tracing breaks down when infection numbers are high

I've seen this repeated in a few articles and I don't understand it. It seems like you just wouldn't be able to keep numbers down entirely but contact tracing seems like it would still help a lot.

it's just another way for the united states to give up without trying because trying seems hard.

My wife spent years doing this for the county health dept where she worked.

Outbreaks of salmonella, e coli, TB, whooping cough, even some std's.

Just trying to gather names and accurate contact info of those you ran across, say 2 weeks ago, is significant enough. Then the abuse from those being contacted. Not everyone, but enough telling you to eff off, just cause, eff you. Especially if it required some action on their part like getting a test. Now add a two week self quarantine, and the push back will go through the roof, both for those being contacted, but also the pool of people willing to be tracers will dry up in really short order.

Contact tracing was the part of her job you couldn't pay her enough to return to.

Online Phil Titola

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I can't believe if someone co tscted you today said you may have been exposed to this virus that anybody would say eff off but such is America