where would you stay in Rome? when i was there last, i was a cheap college student staying in a hostel on the outskirts of town (in other words, i have zero knowledge of nice hotels in the city).
i mean, it depends on what you plan on doing, and what sort of places you enjoy, and how much you walk vs use transport. but the area around termini is kinda boring and an uncomfortable distance (too far to enjoy walking all the time, but so close that you feel stupid paying for the metro) from most stuff.
i guess i'd recommend the trastevere/vatican area if you want somewhere a little peaceful/residential with good restaurants around, but still close enough to walk to a lot of places. or just in the general area of the pantheon/piazza navona/spanish steps zone if you want to be in the center of everything and don't mind the noise & people.
the area past campo d fiori might be good too (peacefulish), dunno.
this is a decent site for finding places, if you're looking more apartmenty than hotely.
http://cross-pollinate.com/