CoronaBro Meltdown/SARS-Covid-19 Spitballing Thread

[MakeItRain]

The Biden Administration:  Real life grim reapers.

https://twitter.com/bennyjohnson/status/1485974711637057539?s=21

I've always said that Ron DeSantis is one of the great medical minds of the 21st century.

[Sandstone Outcropping]

The Biden Administration:  Real life grim reapers.

https://twitter.com/bennyjohnson/status/1485974711637057539?s=21

I've always said that Ron DeSantis is one of the great medical minds of the 21st century.

Fiscal conservatives wanting Medicare to pay for monoclonals (REGN-COV, bam / etes) with no activity against Omicron. I would appreciate it if Sleepy Joe could send us some more of that badass sotrovimab to give to the people my senator told getting chipped was "a deeply personal decision between a patient and their doctor."

Miss those salad days of kicking delta in the balls with REGN-COV or teabagging last winter's strain (alpha??) with straight shots of pure bam. This is making things complicated.

https://twitter.com/ddale8/status/1486036940638019584?s=20

[Dugout DickStone]

DeSantis is such a Trump Lite

[Sandstone Outcropping]

DeSantis is such a Trump Lite

Really needs to up his Random Capital letters during tweets Game if he wants to be a real Old Trumpdaddy 114.

[Trim]

https://twitter.com/42gipsonn/status/1486051715577171968

[wetwillie]

The Biden Administration:  Real life grim reapers.

https://twitter.com/bennyjohnson/status/1485974711637057539?s=21

I've always said that Ron DeSantis is one of the great medical minds of the 21st century.

Fiscal conservatives wanting Medicare to pay for monoclonals (REGN-COV, bam / etes) with no activity against Omicron. I would appreciate it if Sleepy Joe could send us some more of that badass sotrovimab to give to the people my senator told getting chipped was "a deeply personal decision between a patient and their doctor."

Miss those salad days of kicking delta in the balls with REGN-COV or teabagging last winter's strain (alpha??) with straight shots of pure bam. This is making things complicated.

https://twitter.com/ddale8/status/1486036940638019584?s=20

What’s the deal with the monoclonal stuff?  I know two people that didn’t get vaxxed that we’re getting wrekt by delta and got them and got better nearly immediately.  I assume it’s like 2-3k for a round of treatment but why not let people take that if they want to? 

[catastrophe]

I mean the exact explanation is in the quote you quoted. The FDA is not in the business of approving drugs for uses when there is not evidence they work for that use. If another dominant strain rolls around that responds to the treatments they’ll be approved again.

[wetwillie]

I mean the exact explanation is in the quote you quoted. The FDA is not in the business of approving drugs for uses when there is not evidence they work for that use. If another dominant strain rolls around that responds to the treatments they’ll be approved again.

El oh el at the FDA comment, they literally gave it to the President of the United States.   I get it if they don’t want to use up Medicare to pay for it and I’m good with health insurance companies being able to not reimburse for it but if people want to pay out of pocket why not? 

[Rage Against the McKee]

My understanding is that the treatments are effective against other strains, but not omicron. It seems a bit shortsighted to me to pull it, given that there are likely to be future strains that it might be effective against. I'm not a virologist, though.

[catastrophe]

My understanding is that the treatments are effective against other strains, but not omicron. It seems a bit shortsighted to me to pull it, given that there are likely to be future strains that it might be effective against. I'm not a virologist, though.

I am curious what the process is to re-approve it in case it’s effective against another new strain. If it requires a drawn out process with review of a bunch of the same materials then I agree it seems shortsighted. Seems like insurance and doctors should be able to simply not prescribe it for uses where it doesn’t do any good.

Regardless, I have yet to see any good argument that they should be prescribed at this time for omicron COVID cases.

[Sandstone Outcropping]

I mean the exact explanation is in the quote you quoted. The FDA is not in the business of approving drugs for uses when there is not evidence they work for that use. If another dominant strain rolls around that responds to the treatments they’ll be approved again.

El oh el at the FDA comment, they literally gave it to the President of the United States.   I get it if they don’t want to use up Medicare to pay for it and I’m good with health insurance companies being able to not reimburse for it but if people want to pay out of pocket why not?

REGN-COV was awesome against delta. I firmly believe that it saved a lot of unvaxxed lives during delta. The thought is that delta has been totally displaced by omicron at this point in the game. Sadly, only sotrovimab appears to have activity against omicron but it is in very short supply. Sorry if my post above was obtuse. Layered too much sarcasm in there.

Maybe a new strain will emerge that is susceptible to bam / etes or REGN-Cov. I don't think they are throwing the existing doses in the trash. My understanding is that sotrovimab even blocks the original SARS virus (not Wuhan, like the old SARS - COV1 or whatever) so hopefully, they can scale up production so it is as ubiquitous as REGN-COv was during delta.

[wetwillie]

I mean the exact explanation is in the quote you quoted. The FDA is not in the business of approving drugs for uses when there is not evidence they work for that use. If another dominant strain rolls around that responds to the treatments they’ll be approved again.

El oh el at the FDA comment, they literally gave it to the President of the United States.   I get it if they don’t want to use up Medicare to pay for it and I’m good with health insurance companies being able to not reimburse for it but if people want to pay out of pocket why not?

REGN-COV was awesome against delta. I firmly believe that it saved a lot of unvaxxed lives during delta. The thought is that delta has been totally displaced by omicron at this point in the game. Sadly, only sotrovimab appears to have activity against omicron but it is in very short supply. Sorry if my post above was obtuse. Layered too much sarcasm in there.

Maybe a new strain will emerge that is susceptible to bam / etes or REGN-Cov. I don't think they are throwing the existing doses in the trash. My understanding is that sotrovimab even blocks the original SARS virus (not Wuhan, like the old SARS - COV1 or whatever) so hopefully, they can scale up production so it is as ubiquitous as REGN-COv was during delta.

Hadnt heard of the ‘mab that’s Encouraging.  Hearing anything on that Pfizer pill?

[Sandstone Outcropping]

I mean the exact explanation is in the quote you quoted. The FDA is not in the business of approving drugs for uses when there is not evidence they work for that use. If another dominant strain rolls around that responds to the treatments they’ll be approved again.

El oh el at the FDA comment, they literally gave it to the President of the United States.   I get it if they don’t want to use up Medicare to pay for it and I’m good with health insurance companies being able to not reimburse for it but if people want to pay out of pocket why not?

REGN-COV was awesome against delta. I firmly believe that it saved a lot of unvaxxed lives during delta. The thought is that delta has been totally displaced by omicron at this point in the game. Sadly, only sotrovimab appears to have activity against omicron but it is in very short supply. Sorry if my post above was obtuse. Layered too much sarcasm in there.

Maybe a new strain will emerge that is susceptible to bam / etes or REGN-Cov. I don't think they are throwing the existing doses in the trash. My understanding is that sotrovimab even blocks the original SARS virus (not Wuhan, like the old SARS - COV1 or whatever) so hopefully, they can scale up production so it is as ubiquitous as REGN-COv was during delta.

Hadnt heard of the ‘mab that’s Encouraging.  Hearing anything on that Pfizer pill?

Paxlovid (Pfizer pill) is supposed to be effective. It isn't available out here yet. The data for it look good but also looks like there are important drug-drug  interactions that need to be checked out for patients. I hope it gets here soon! Some data for fluvoxamine which is now in KU Med's outpatient C19 protocol (repurposed old-school antidepressent with antiviral/anti-inflammatory properties) look good but I think tolerability (sedation, fatigue) may be an issue for a lot of patients. It is starting to be used some but I think tolerability and drug-drug interactions will be issues for a significant number of patients. The studied dose for fluvoxamine is 100mg twice daily x 10 days. The normal starting dose for fluvoxamine is 50mg ONCE daily so the studied dose for COVID purposes is whopping.

[sys]

Seems like insurance and doctors should be able to simply not prescribe it for uses where it doesn’t do any good.

doctors, as a group, aren't smart enough to pull that off.

[MakeItRain]

Seems like insurance and doctors should be able to simply not prescribe it for uses where it doesn’t do any good.

doctors, as a group, aren't smart enough to pull that off.

This is also what was happening before there were regulatory agencies, and likely millions of people died at the hands of quack doctors. I mean this is exactly why the regulatory agencies created. @catastrophe did you not learn about the Goat Gland Doctor in Kansas History class?

https://en.wikipedia.org/wiki/John_R._Brinkley

[Sandstone Outcropping]

Seems like insurance and doctors should be able to simply not prescribe it for uses where it doesn’t do any good.

doctors, as a group, aren't smart enough to pull that off.

This is also what was happening before there were regulatory agencies, and likely millions of people died at the hands of quack doctors. I mean this is exactly why the regulatory agencies created. @catastrophe did you not learn about the Goat Gland Doctor in Kansas History class?

https://en.wikipedia.org/wiki/John_R._Brinkley

Great book about Brinkley for those who are interested: https://www.amazon.com/Charlatan-Americas-Dangerous-Huckster-Flimflam/dp/0307339890/ref=pd_sbs_1/139-7484737-6356167?pd_rd_w=yS6tY&pf_rd_p=dfec2022-428d-4b18-a6d4-8f791333a139&pf_rd_r=RY9Y8RNRPGFXC972SGA6&pd_rd_r=8c637d9a-84f7-4353-ade3-e160b6626fbb&pd_rd_wg=eDjhe&pd_rd_i=0307339890&psc=1

[steve dave]

These vaccines are incredible (I realize almost everyone here already knows and acknowledges that, I just enjoy sharing)

[Sandstone Outcropping]

These vaccines are incredible (I realize almost everyone here already knows and acknowledges that, I just enjoy sharing)

Doing what they were meant to do. Hope they hold up this well against severe disease and death with the next variant. Did a great job preventing mild infections until the Omicron phase, as well.

[wetwillie]

So what stage are we in now? Is the pandemic essentially over come spring and it’s just an annual shot like the flu shot going forward? I assume it can’t just keep stacking 500k bodies a year into perpetuity.

[catastrophe]

Seems like insurance and doctors should be able to simply not prescribe it for uses where it doesn’t do any good.

doctors, as a group, aren't smart enough to pull that off.

This is also what was happening before there were regulatory agencies, and likely millions of people died at the hands of quack doctors. I mean this is exactly why the regulatory agencies created. @catastrophe did you not learn about the Goat Gland Doctor in Kansas History class?

https://en.wikipedia.org/wiki/John_R._Brinkley

Actually that doesn’t ring a bell. The point is well taken but obviously there’s a difference between prescribing something that does no good and prescribing something that is actually harmful.

[michigancat]

So what stage are we in now? Is the pandemic essentially over come spring and it’s just an annual shot like the flu shot going forward? I assume it can’t just keep stacking 500k bodies a year into perpetuity.

We're in the stage where omicron is spiking in some of the country and subsiding in others.

Who knows what it will be like moving forward, omicron definitely brought up new challenges that I don't think anyone of note really predicted. Still, I'd guess that to 95% of the country, this is over and their lives won't be affected again significantly.

Like for you specifically, wetwillie, is Covid impacting your life in any meaningful way right now?

[Kat Kid]

So what stage are we in now? Is the pandemic essentially over come spring and it’s just an annual shot like the flu shot going forward? I assume it can’t just keep stacking 500k bodies a year into perpetuity.

We're in the stage where omicron is spiking in some of the country and subsiding in others.

Who knows what it will be like moving forward, omicron definitely brought up new challenges that I don't think anyone of note really predicted. Still, I'd guess that to 95% of the country, this is over and their lives won't be affected again significantly.

Like for you specifically, wetwillie, is Covid impacting your life in any meaningful way right now?

It is stupid to pretend like COVID isn't still meaningfully impacting people's lives even if they are vaccinated.  Come on.

[mocat]

i mean, as we speak there are who knows how many a&m grads aimlessly walking around downtown LA looking for french fries

[Phil Titola]

Looks like only a handful of states haven't seen their downturn start

https://www.nytimes.com/interactive/2021/us/covid-cases.html

After I test negative today it will be back to not impacting my life at all much like since I got my vaccine.  Life around me as definitely changed so that's impactful (closed restaurants, empty office, PITA travel requirements)

[bucket]

Looks like only a handful of states haven't seen their downturn start

https://www.nytimes.com/interactive/2021/us/covid-cases.html

After I test negative today it will be back to not impacting my life at all much like since I got my vaccine.  Life around me as definitely changed so that's impactful (closed restaurants, empty office, PITA travel requirements)

I thought I saw on Twitter that cases are still climbing in Kansas. At work we're still seeing a positivity rate of 20%. I've cut out happy hour and eating out as a result.