I'm going to pull the trigger on a Nest thermostat this winter. 
I highly recommend you don't. I would go with a Honeywell 8000 or Prestige 2.0 with RedLink Gateway.
Why? I only know two ppl with a Nest(both love it) but what I have read on it makes it sound like it is a good choice for how I roll. Open to other info though.
Primarily discourage it because of the sourcing of the product. Since you are buying directly from the OEM, the contractor isn't really on your side come warranty time. It is my understanding that it has to be installed by a pro.
From a functionality standpoint, I don't have any objections. It does the same thing as the Honeywell stats with similar interface (app or computer).
So, why either of the Honeywell stats? Both deliver Web interface capabilities. The 8000 doesn't need the Redlink Gateway but you get the more functionality with it. Wireless remote temperature and humidity sensing for outdoor information (not sourced from Web). My company offered lifetime warranty on our Honeywell stats. Yes. Lifetime. They're that solid.
Anyhow, that's my 2 cents.