Seeing as I how I made a living for about 6 years in the sports wagering industry, why don't all you geniuses clear things up for all of us...
This should be fun.

For starters, nobody sets a line days in advance of releasing it to the public.
Are you rough ridin' kidding me?!?!? LVSC (Las Vegas Sports Consultants) sets "opening lines", but doesn't take wagers. What in the hell makes you think for a second that their computers didn't have the opening line determined for this contest within HOURS of when the KSU & NU games ended on Setp. 27??
At that point, they had all the statistical information thaey needed to set not only the point spread, but also the TOTAL. Just because they didn't realease them, doesn't mean they weren't calculated.
Same with all the casinos, offshore books, etc. that don't use LVSC as their starting point.
Traditionally, sides come out on Sunday eve about 5pm CST or so, give or take a half hour and Totals come out on Tuesday mornings around 10am. All this info is processed by computer within minutes of both teams games ending for the subsequent contest. When both teams have a bye the weekend before lines are released, I GUARANTEE that the line was set but not released LAST Sunday, Sept 28 pending any unannounced practice injuries, suspensions, etc. throughout the open week that would have caused the line to go off the board.