You've got an offensive line used to a lot of 2 back power/counter/trap (and frankly not very good the last couple years) running 1 back zone run schemes. Its going to be an adjustment, both for the oline and the backs. Backs will now have more freedom to choose a gap as it develops, but that will take reps. We did some of that with Sproles b/c he had those skills, but I'm not sure that's Clayton's strength. In any case, we're going to be a pretty pure zone team with is a pretty big adjustment.
All that said, that will effect our passing game, and we may have to lean on the passing game quite a bit more to get yards, especially without the QB run game. I'm not expecting this team to be in the upper half of the league in rushing, probably less than 200 per game; so if we're going to win we better be throwing for 300+ game in and game out, whoever the QB is. Be ready, its going to be a major transition watching Wildcat football.