I have a very low FBIQ but based on what I've seen/read so far here's my prediction:
North
1. Nebraska
2. Missouri
3. Kansas
4. Kansas State
5. Colorado
6. Iowa State
South
1. Oklahoma
2. Texas
3. Texas A&M
4. Oklahoma State
5. Texas Tech
6. Baylor
Most of it is just a toss up but I do feel pretty confident about three things: Oklahoma will win the Big 12 (easily) and Baylor and Iowa State will finish last in their respective divisions.