Hey guys, let's discuss psychedelics

[steve dave]

I want to reiterate what I posted at some point in this thread that Psilocybin mushrooms are an incredible thing for dealing with mortality. if you or a loved one are dying or have someone who is I cannot encourage you enough to look into them. that's my irl psa for today.

[Pete]

I want to reiterate what I posted at some point in this thread that Psilocybin mushrooms are an incredible thing for dealing with mortality. if you or a loved one are dying or have someone who is I cannot encourage you enough to look into them. that's my irl psa for today.

Yeah, one night I told one of Limestone and my other roommates the absolute complete real secret of the universe and our purpose as humans.  It was a  fantastic idea, but I cannot remember what it was.  I just know that I knew that it was the best insight into the mystery of life, ever. Again, zero idea now what that was.

[stunted]

Meth, yay or nay?

[Pete]

That’s horrible stuff. Stay away.

[Pete]

That’s horrible stuff. Stay away.

No offense to anyone recovering from or thinking about recovering from it.

Just avoid the stuff if you can.

[KITNfury]

Meth, yay or nay?

There's a reason people like it. There's a reason people say stay away.

[Sandstone Outcropping]

Paper in the New England this week with promising early results for use of psilocybin to treat depression:

https://www.nejm.org/doi/full/10.1056/NEJMoa2206443?query=RES&cid=NEJM+Resident+Briefing%2C+November+3%2C+2022+DM1624232_NEJM_Non_Subscriber&bid=1244175369

In this phase 2 trial involving participants with treatment-resistant depression, psilocybin at a single dose of 25 mg, but not 10 mg, reduced depression scores significantly more than a 1-mg dose over a period of 3 weeks but was associated with adverse effects. Larger and longer trials, including comparison with existing treatments, are required to determine the efficacy and safety of psilocybin for this disorder.

[steve dave]

but was associated with adverse effects like time travel and your bud going on repeat and saying the same thing 12 times in a row but irl he just said it once and your brain rewound it.


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[Spracne]

Adverse effects like getting arguably sexually assaulted by a girl on the floor of your foyer while all you're trying to do is eat your Pizza Shuttle that just arrived.

[yoga-like_abana]

Paper in the New England this week with promising early results for use of psilocybin to treat depression:

https://www.nejm.org/doi/full/10.1056/NEJMoa2206443?query=RES&cid=NEJM+Resident+Briefing%2C+November+3%2C+2022+DM1624232_NEJM_Non_Subscriber&bid=1244175369

In this phase 2 trial involving participants with treatment-resistant depression, psilocybin at a single dose of 25 mg, but not 10 mg, reduced depression scores significantly more than a 1-mg dose over a period of 3 weeks but was associated with adverse effects. Larger and longer trials, including comparison with existing treatments, are required to determine the efficacy and safety of psilocybin for this disorder.

haven't they known all of this for a long time?

[Sandstone Outcropping]

Paper in the New England this week with promising early results for use of psilocybin to treat depression:

https://www.nejm.org/doi/full/10.1056/NEJMoa2206443?query=RES&cid=NEJM+Resident+Briefing%2C+November+3%2C+2022+DM1624232_NEJM_Non_Subscriber&bid=1244175369

In this phase 2 trial involving participants with treatment-resistant depression, psilocybin at a single dose of 25 mg, but not 10 mg, reduced depression scores significantly more than a 1-mg dose over a period of 3 weeks but was associated with adverse effects. Larger and longer trials, including comparison with existing treatments, are required to determine the efficacy and safety of psilocybin for this disorder.

haven't they known all of this for a long time?

This is the first time I've seen something published in a high-profile journal like NEJM.

[BIG APPLE CAT]

at some point i want to just like, go to Sweden or Norway or whatever and just stroll into one of those LSD clinics and have a doc administer to me and suddenly i know calculus 5

[Spracne]

@BAC, if you want to see the sun breaking through your environs in fractal patterns, you don't need to travel all the way to Scandinavia. I got your back.

[CNS]

 

[star seed 7]

Last weekend my drug dealer gifted me a gram of mushrooms just to try out, will it make me undepressed?

[Spracne]

Last weekend my drug dealer gifted me a gram of mushrooms just to try out, will it make me undepressed?

I'm not a doctor (other than the juris variety) or scientist, but yes. Chomp chomp.

[CHONGS]

https://en.m.wikipedia.org/wiki/Echinopsis_pachanoi

[nicname]

Last weekend my drug dealer gifted me a gram of mushrooms just to try out, will it make me undepressed?

Have you ever microdosed? I've never eaten less than 7g of mushrooms at a time. I'm interested in a trusted review of the microdose feels.

[Spracne]

Nic likes to get weird. 7 grams is an absurd floor.

[KITNfury]

Nic likes to get weird. 7 grams is an absurd floor.

Yea it is. I used to trip balls on half that. I eventually tired of those intense trips and would just eat 1.5-2g for very light visuals, body highs, and the ability to talk to other people.

[nicname]

Nic likes to get weird. 7 grams is an absurd floor.

Yea it is. I used to trip balls on half that. I eventually tired of those intense trips and would just eat 1.5-2g for very light visuals, body highs, and the ability to talk to other people.

You're prob right. I think it was actually 3.5 grams, or about 1/8 of an ounce. But I def tripped balls every time.

I think asteriskhead used to microdose from time to time.

[nicname]

Yes, best not done around bunches people or anywhere loud. Walking through east side MHK neighborhoods at night was a treat. I always ate an eighth all at once never tried any other way

Yeah it was an 8th.

[BIG APPLE CAT]

@BAC, if you want to see the sun breaking through your environs in fractal patterns, you don't need to travel all the way to Scandinavia. I got your back.

Real talk, Starting in January my company is switching over from accrued PTO to unlimited but no accrual. So basically ppl like me have a crap ton of PTO to burn between now and the end of the year. Mrs BAC was like “just like, take some days off to do whatever”

So like, I’m totally down to get weird. Maybe we could get AST to cook something amazing, holy crap this could rule so hard. This has been real talk with BAC

[Spracne]

Mrs. BAC sounds like a cool lady.

[CNS]

Last weekend my drug dealer gifted me a gram of mushrooms just to try out, will it make me undepressed?

Not without like 4g more and some therapy during, unfortunately. It will be fun though.