In my opinion, the difference between being the 4 and the 5 is minuscule compared to the difference between being the 5 and the 6 overall seed.
6-8 seeds get UK, UK and 'Cuse. DO NOT WANT!
Currently, WVU (3) and Duke (4) have us (8) beat on strength of schedule. Right now, Duke (2) has us (5) beat on RPI, but we beat WVU (6)
http://www.cbssports.com/collegebasketball/polls/rpi/index1. These two seem like the leaders to beat us to the 5 seed. Nova has a SOS of 30+, and Pitt and GTown are 5+ spots lower on the RPI with a couple more losses, but do have good SOS.
WVU's losses are all pretty good, with home losses only to Villanova and 'Cuse. Their worst loss is Notre Dame (81 rpi), and that's not too bad. They beat Ole Miss and aTm, and Ohio State.
Duke's losses are all road losses at GTown (10 rpi), Wisconsin (17 RPI), GT (30 rpi), and NC State (118).
In summary, here is how we stack up against Duke and WVU: